Cyclobenzaprine: Uses, Interactions, Mechanism of Action DrugBank Online

People with liver damage or liver problems should not take cyclobenzaprine, as the interaction on the liver is potentially dangerous. While the FDA indicates that there have not been enough studies involving people with hepatic impairment, the potential for the drug interacting negatively with the liver is high. A doctor will typically prescribe 5 mg of cyclobenzaprine, three times per day.

If you have muscle spasms or muscle pain and plan to take skeletal muscle relaxants, please work with your healthcare provider to find the one that works best for you. Keep in mind that along with medications for short-term alleviation of pain and discomfort, rest and physical therapy can help with long-term pain relief and function. Cyclobenzaprine (sye” kloe ben’ za preen) is a tricyclic antidepressant derivative that relaxes skeletal muscle by an unknown mechanism of action. Cyclobenzaprine is also a central nervous system depressant, and its efficacy may be related to its sedative effects. Cyclobenzaprine is used for the treatment of painful muscle spasms from acute muscle conditions. The recommended dosage in adults is 5 to 10 mg three times daily for 3 to 4 weeks.

Clinical Trials

Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (γ) and alpha (α) motor systems. Cyclobenzaprine HCl relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to central nervous system disease. In order to protect against the rare but potentially critical manifestations described above, obtain an ECG and immediately initiate cardiac monitoring. Protect the patient’s airway, establish an intravenous line and initiate gastric decontamination.

Tums Anti-Gas/Antacid Oral: Uses, Side Effects, Interactions … – WebMD

Tums Anti-Gas/Antacid Oral: Uses, Side Effects, Interactions ….

Posted: Tue, 30 Sep 2014 03:31:21 GMT [source]

Another potential side effect of Flexeril is overdose if an individual takes too much of the drug. Although Flexeril doesn’t produce a euphoric high like many other drugs, people still misuse it due to its relaxing effects; many will increase dosages to amplify those effects. A Flexeril overdose can cause severe health problems such as cardiac arrest, dangerously low blood pressure, and seizures. Central nervous system depression, seizures, heart attack, and even death can occur. The overall incidence of adverse reactions among patients in the surveillance program was less than the incidence in the controlled clinical studies.

What do I Need to Know About Taking Flexeril?

Also avoid driving, operating machinery, or other hazardous activities until you know how cyclobenzaprine affects you. Sometimes people will even have a heart attack or develop seizures. In order to quit safely, you need to opt for professional Flexeril rehab. Getting treated for your Flexeril addiction professional has so many benefits. For one, you are able to learn from people who understand how this type of addiction works.

• Getting treated for your Flexeril addiction professional has so many benefits.
• Flexeril works by acting on the central nervous system, blocking pain sensations that would otherwise travel from sore and spasming muscles to the brain.
• In light of these findings, therapy with FLEXERIL in the elderly should be initiated with a 5 mg dose and titrated slowly upward.
• If the drug screen is testing for TCA’s, Flexeril may show up.

It can also lead to impaired coordination, which can cause accidents. Also, taking a muscle relaxant with alcohol can increase the chance of abuse or dependence. Have you ever “thrown out your back” or experienced an injury or sprain where you feel like your muscles are spasming and so tight that you can’t move? If so, your healthcare provider may have prescribed a muscle relaxant to help your symptoms.

Flexeril is one of the most studied muscle relaxants; thus, it has more supporting evidence for its effectiveness. In a systematic review, it was found that, in general, muscle relaxants are comparable in effectiveness. This review included other muscle relaxants such as metaxalone, baclofen, tizanidine, orphenadrine, and chlorzoxazone. Robaxin or Flexeril are usually prescribed to treat musculoskeletal pain such as neck pain. Both drugs are also often used to treat low back pain, a common problem in adults in the US.

These medications should only be taken if their benefits outweigh the risks. Muscle relaxants should only be taken with medical guidance from a doctor. Examples of drugs that can cause interactions with cyclobenzaprine are listed below. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Ell your doctor if your condition lasts after 2 to 3 weeks or if it gets worse. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of cyclobenzaprine toxicity. Safety and effectiveness of can flexeril be crushed FLEXERIL in pediatric patients below 15 years of age have not been established. FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants. Tricyclic antidepressants have been reported to produce arrhythmias, sinus tachycardia, prolongation of the conduction time leading to myocardial infarction and stroke.

It is a very powerful muscle relaxer, and it works quite well. It occurred to me that it might work even better if I used a little more than I normally would. I waited until I had a couple of days when I would be at home, by myself. When I only took Flexeril 10mg, it produced a type of “hangover” effect the next day. I woke up in the morning and I took one 10mg tab of Flexeril, sat back and waited for the high.